d3 receptor — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T5383	D3-βArr	NCGC00379308	TSH Receptor
	D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.		TSH Receptor
T6430L	Calcifediol monohydrate	25-hydroxy Vitamin D3 monohydrate	Endogenous Metabolite
	Calcifediol monohydrate (25-hydroxy Vitamin D3 monohydrate), the main circulating metabolite of vitamin D3, is a potent VDR inhibitor.		Endogenous Metabolite
T6316	Calcitriol	Topitriol,Rocaltrol,Calcijex,RO215535,1,25-Dihydroxyvitamin D3	Endogenous Metabolite
	Calcitriol (1,25-Dihydroxyvitamin D3) is a metabolite of vitamin D and a vitamin D receptor (VDR) agonist (IC50=0.4 nM). Calcitriol increases intestinal absorption of calcium and phosphorus, and increases bone resorption...		Endogenous Metabolite
T6430	Calcifediol	U 32070E,25-hydroxy Vitamin D3,RO 8-8892	Endogenous Metabolite
	Calcifediol (U 32070E)(Ki of 3.9 μM), a major circulating metabolite of vitamin D3, works as a competitive inhibitor. It (ED50=2 nM)also inhibits PTH secretion and mRNA.		Endogenous Metabolite
T6374	Alfacalcidol	Bondiol,Etalpha,1-hydroxy Vitamin D3,1.alpha.-Hydroxyvitamin D3,1-hydroxycholecalciferol	Others
	Alfacalcidol (Etalpha) (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3) is a non-selective VDR activator medication.		Others
T1135	Vitamin D3	Cholecalciferol,Colecalciferol	Endogenous Metabolite
	Vitamin D3 (Cholecalciferol) , a naturally occurring form of vitamin D, activates an H305F/H397Y mutant vitamin D receptor (VDR).		Endogenous Metabolite
T83776	Dopamine D3 Receptor Agonist 13a
	Dopamine D3 receptor agonist 13a selectively targets the dopamine D3 receptor over dopamine D1, D2, and D4 receptors, with affinities (Ki values) of 0.14, 4,600, 2.85, and 756 nM, respectively. It also interacts with ser...
T62946	Dopamine D3 receptor antagonist-2
	Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.
T64024	Dopamine D3 receptor antagonist-1
	Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeutic potential for central nervous system disorders.
T62528	Dopamine D3 receptor ligand-1
	Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki: 715 nM).
T21667	FAUC-365	FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide,FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide	Dopamine Receptor
	FAUC-365 is a D3 dopamine receptor agonist.		Dopamine Receptor
T3431	Pardoprunox hydrochloride	SLV-308 hydrochloride,DU-126891 hydrochloride	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
	Pardoprunox hydrochloride (SLV-308 hydrochloride) is a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist, D2 (pKi = 8.1) and D3 receptor (pKi = 8.6) partial agonist and 5-HT1A recept...		Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor
T7553	(+)-PD 128907 hydrochloride		Dopamine Receptor
	(+)-PD 128907 hydrochloride is an agonist of D3 dopamine receptor .		Dopamine Receptor
T23143	PG 01037 dihydrochloride	PG-01037 2HCl	Dopamine Receptor
	PG 01037 dihydrochloride (PG-01037 2HCl) is a potent and selective dopamine D3 receptor antagonist with a Ki of 0.7 nM.		Dopamine Receptor
T10213	A-437203	ABT-925,A37203,Lu201640	Dopamine Receptor
	A-437203 (Lu201640) is A kind of based on 1 h - pyrimidin - 2 - one sca ﬀ old, selective, new powerful d3 receptor antagonist, on D2, d3, and D4 receptor, Ki value 71, respectively 1.6 and 6220 nM.		Dopamine Receptor
T12861	SB-277011	SB-277011A	Dopamine Receptor
	SB-277011 (SB-277011A) is a specific antagonist of the dopamine D3 receptor with pKi values of 8.0, 6.0, 5.0, and <5.2 for D3 receptor, D2 receptor, 5-HT1D, and 5-HT1B respectively.		Dopamine Receptor
T6142	PD128907 HCl		Dopamine Receptor
	PD128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor.		Dopamine Receptor
T4577	Cariprazine	RGH-188	Dopamine Receptor , 5-HT Receptor
	Cariprazine (RGH-188) is a novel antipsychotic drug candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM).		Dopamine Receptor , 5-HT Receptor
T8382	Cariprazine hydrochloride	Cariprazine HCl,RGH188 hydrochloride	Dopamine Receptor , 5-HT Receptor
	Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)		Dopamine Receptor , 5-HT Receptor
T15686	L-741626	3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole	Dopamine Receptor
	L-741626 (3-(4-(4-Chlorophenyl-4-hydroxypiperidino)methyl)indole) is a selective antagonist of D2 dopamine receptor (Ki: 2.4, 100, and 220 nM for human D2, D3 and D4 receptors respectively).		Dopamine Receptor